Bell is Hestia's first Familia member and love interest. Hestia appears to have been in love with Bell since he first joined her Familia, as no one wanted to join her and the two were alone in the world. Hestia tends to get jealous very easily whenever Bell thinks about or interacts with other girls. Hestia also tends to sneak into his bed to sleep with him. Hestia worries about Bell's health and safety whenever he enters the dungeon.
Hestia has been shown to dislike Ais, namely because Ais is the reason for Bell's sudden growth in terms of strength and skills, as well as jealousy towards Ais' beauty. Hestia even stated that the reason she didn't tell Bell about his growth state was not only because others will be after him, but because of Ais, even stating it was ninety percent of the reason.
Hestia and Hephaestus appear to be very close friends, with Hestia even living with Hephaestus for a time, however, she was eventually kicked out by Hephaestus and told to find her own Familia. They were close enough for Hephaestus to create a weapon for Hestia's Familia member Bell Cranel. During a conversation with Welf, Hephaestus reveals that the reason the two are close friends is that Hestia was the only one to not laugh or mock her for her disfigured eye.
Hestia and Loki appear to have a rival goddess relationship that has lasted since the time they were in heaven until present. Loki tends to make fun of her small Familia as well as being a 'runt'. In return, Hestia makes fun of Loki's flat chest, much to Loki's chagrin. Their relationship is rather unfriendly, purposely keeping Bell and Ais apart from each other. While their relationship nears hostility, they do not appear to fight outside of verbal arguments, and Hestia even admits to one of Loki's virtues, that being her love for her children.